Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease

Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease

Parkinson's disease (PD) is the most common cause of neurodegenerative movement disorder and the second most common cause of dementia. Genes are thought to have a stronger effect on age-at-onset of PD than on risk, yet there has been a phenomenal success in identifying risk loci but not age-at-onset modifiers. We conducted a genome-wide study for age-at-onset. We analysed familial and non-famil...

Nongenetic factors as modifiers of the age of onset of familial Alzheimer's disease.

OBJECTIVE The purpose of this research was to identify environmental and personal factors that could be related to the variability in the age of onset of familial Alzheimer's disease (FAD) (36-62 years). METHODS A sample was taken of 49 subjects with FAD and with the mutation E280A in the presenilin-1 gene on chromosome 14; the sample was divided into two subgroups: 27 individuals with age of...

Familial correlations for age at onset and age at death in Huntington's disease.

Investigation on Genetic Modifiers of Age at Onset of Major Depressive Disorder

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Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.

IMPORTANCE The present study identified potential genetic modifiers that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onset in PSEN1 mutation carrier families, and further investigation of these modifiers may provide insight into the pathobiology of AD and potential therapeutic measures. OBJECTIVE To identify genetic variants that modify age at o...